MACOP-B Chemotherapy Regimen

MACOP-B is an acronym that represents a commonly used combination chemotherapy regimen in cancer treatment.

MACOP-B consists of the following drugs:

  • Methotrexate
  • ARA-C (Cytarabine)
  • Cyclophosphamide
  • Oncovin (vincristine)
  • Prednisone
  • Bleomycin

A Typical MACOP-B Regimen

(regimens should be tailored to the individual)

Cycle length: 1 week

Number of cycles: 12

Weeks 1,3,5,7,9,11
Day 1 of every odd-numbered week: Doxorubicin (IV push), cyclophosphamide (IV)
Weeks 2,4,6,8,10,12
Day 1 of weeks 2,6,10: Methotrexate (IV infusion) and leucovorin rescue
Day 1 of every even-numbered week: Vincristine (IV push)
Day 1 of weeks 4,8,12: Bleomycin (IV push)
Days 1-69: Prednisone (oral)
Days 70-84: Prednisone (oral) tapered down
Vomit potential?
Weeks 1,3,5,7,9,11: Moderately high
Weeks 2,6,10: Moderately high
Weeks 4,8,12: None

What it's effective for

The MACOP-B chemotherapy regimen has long been used in the treatment of mediastinal B-cell non-Hodgkin lymphomas, ones that are typically in advanced stages and considered aggressive.

Side effects

Side effects associated with MACOP-B include varying grades of leukopenia, mucositis, infections and anemia. Additionally, since this regimen includes bleomycin, pulmonary toxicity and other lung problems are not uncommon. More on chemotherapy side effects.


  • Boyiadzis, Michael M. et al. Hematology-Oncology Therapy. 2007. New York: McGraw Hill, Medical Publishing Division.

Significant studies relating to MACOP-B


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